Basic Principles and Applications of Monoclonal Antibodies in the Management of Carcinomas: The Richard and Hinda Rosenthal Foundation Award Lecture1

How Cancer Cells Evade Chemotherapy: Sixteenth Richard and Hinda Rosenthal Foundation Award Lecture1

Basic principles and applications of monoclonal antibodies in the management of carcinomas: the Richard and Hinda Rosenthal Foundation award lecture.

The advent of hybridoma technology in 1975 (1) represented a quantum leap in the field of tumor immunology. For the first time, B-lymphocytes from immunized hosts could be immor talized by means of fusion with drug selected non-immunoglobulin secretor murine myeloma cells. These fused cell products could then be cloned and propagated indefinitely. The super natant fluids of cultures from litera...

Tumor Biology and Clinical Trials: The Richard and Hinda Rosenthal Foundation Award Lecture1

Laboratory research is often described as basic and clinical research, prognostic or empirical. In this address, the point is made that research may be clinical or labora tory. Good clinical research may give important biological answers. Breast cancer clinical trials are described in terms of their biological interpretation. A list of significant biolog ical questions that need answering are p...

Tumor biology and clinical trials: the Richard and Hinda Rosenthal Foundation Award Lecture.

Laboratory research is often described as basic and clinical research, prognostic or empirical. In this address, the point is made that research may be clinical or laboratory. Good clinical research may give important biological answers. Breast cancer clinical trials are decribed in terms of their biological interpretation. A list of significant biological questions that need answering are pres...

Therapeutic Applications of Monoclonal Antibodies in Multiple Sclerosis

Despite the various therapies available, the use of monoclonal antibodies is a highly specific approach that has only recently been of interest to researchers. The properties of antibodies have led to their use in the treatment of various diseases, including cancer, Alzheimer's disease, diabetes and multiple sclerosis (MS). MS, a chronic inflammatory disease, occurs commonly in young adults. Th...